<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:54f0c616-30c9-4572-91b5-ef42693a5c3d,g:fd39dffb-8df9-4ac2-aab0-da4f9402963c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.cardiffoncology.com/role/Cover" xlink:type="simple" xlink:href="crdf-20220609.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.cardiffoncology.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_16e99279-383a-4b7c-b117-65c48fbfcde8" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_DocumentType_16e99279-383a-4b7c-b117-65c48fbfcde8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_81aaf908-34a8-44e7-9001-aa3ac28b81c3" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_DocumentPeriodEndDate_81aaf908-34a8-44e7-9001-aa3ac28b81c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_68f1a835-cbff-4a2c-acf1-76226dd031e2" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityRegistrantName_68f1a835-cbff-4a2c-acf1-76226dd031e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_38c2101c-0a84-4bd0-abb4-447f070ad69c" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityFileNumber_38c2101c-0a84-4bd0-abb4-447f070ad69c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_a1145b0a-75cf-4054-86dc-cc28e562ef99" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityTaxIdentificationNumber_a1145b0a-75cf-4054-86dc-cc28e562ef99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_1881ec01-28e4-482f-8719-268b695d8417" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityAddressAddressLine1_1881ec01-28e4-482f-8719-268b695d8417" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_07394432-043f-4c4e-8ef2-04be37c2696f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityAddressStateOrProvince_07394432-043f-4c4e-8ef2-04be37c2696f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_660a9de0-2b8e-4baa-8e31-3e4c9ad8d952" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityAddressPostalZipCode_660a9de0-2b8e-4baa-8e31-3e4c9ad8d952" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_cd659a1d-ea98-4f3d-8c9d-42ee9ce900b5" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityAddressCityOrTown_cd659a1d-ea98-4f3d-8c9d-42ee9ce900b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_1fdadf96-6b6d-4c94-bcdb-d794fc37663b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_CityAreaCode_1fdadf96-6b6d-4c94-bcdb-d794fc37663b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_5df708ea-758e-4bd6-a680-f686dfe916fa" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_LocalPhoneNumber_5df708ea-758e-4bd6-a680-f686dfe916fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_31e7ee7c-4423-46f9-a12e-d4db8a1c60e8" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_Security12bTitle_31e7ee7c-4423-46f9-a12e-d4db8a1c60e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_edbf699c-8f08-487e-b0e8-848f1065ea0a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_TradingSymbol_edbf699c-8f08-487e-b0e8-848f1065ea0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_639331a6-fa24-49c9-8f84-5c3ea887dbdb" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_WrittenCommunications_639331a6-fa24-49c9-8f84-5c3ea887dbdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_21dd1149-697f-4f23-96f9-01a792d0cc9e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_SolicitingMaterial_21dd1149-697f-4f23-96f9-01a792d0cc9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_68b2a3c4-537b-4e8f-bcae-2e3e2a2bc1a0" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_PreCommencementTenderOffer_68b2a3c4-537b-4e8f-bcae-2e3e2a2bc1a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_3bf43ca1-03d9-46a7-8ad1-758799e83303" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_3bf43ca1-03d9-46a7-8ad1-758799e83303" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_3e19cbac-367e-4448-949f-72c13a79f641" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityEmergingGrowthCompany_3e19cbac-367e-4448-949f-72c13a79f641" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_7324037d-5260-4260-bd93-ff7473dc60f4" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityIncorporationStateCountryCode_7324037d-5260-4260-bd93-ff7473dc60f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_d88d7a52-a67d-4bf6-a175-4aebd8a27672" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_EntityCentralIndexKey_d88d7a52-a67d-4bf6-a175-4aebd8a27672" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_3726f054-33eb-43d0-956f-83f3812c6e0e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_eb00fd7b-02a9-4339-b8fd-625a99f3b290" xlink:to="loc_dei_AmendmentFlag_3726f054-33eb-43d0-956f-83f3812c6e0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
