United States securities and exchange commission logo May 29, 2020 Mark Erlander Chief Executive Officer Cardiff Oncology, Inc. 11055 Flintkote Avenue San Diego, CA 92121 Re: Cardiff Oncology, Inc. Registration Statement on Form S-1 Filed May 22, 2020 File No. 333-238623 Dear Mr. Erlander: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Laura Crotty at (202) 551-7614 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Jeffrey Fessler